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Beyond its established connections with upregulated lysosomal activity, glutaminolysis, and tricarboxylic acid cycle function, ferroptosis can transition to an apoptotic phenotype when driven by intense endoplasmic reticulum stress and a metabolic shift favoring phosphatidylcholine over phosphatidylethanolamine (30)
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A study examining the use of pirfenidone enrolled 105 IPF patients to receive either the study drug or placebo [21]
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