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The data was quantile normalized and peak-corrected [36], [37], and low quality probes (detection p-value≥0.01), 92,667 probes overlapping SNPs either at or within 10 bp of the targeted CpG site, and invariable probes with a mean beta-value ≥0.95 or ≤0.05 across case and control samples were removed from analysis [38], [39]
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