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Moreover, the reducing agent acts in a catalytic manner through the formation of an intermediate thioester, as depicted in the mechanism schematized in Figure 3A (see below)

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Combined methylmalonic aciduria and homocystinuria Late onset disease has better prognosis compared to early onset forms Methods: Case 1: 20‐year‐old male with history of recurrent focal seizures since 5 years of age, acute encephalopathy at 6 years of age followed by poor scholastic performance and progressive spastic paraparesis‐ wheelchair bound since past 2 years