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Symptoms of B12 deficiency include: Fatigue Low mood or personality/mood changes Irritability Lethargy Headaches Palpitations Loss of appetite Pale yellow tint to the skin A feeling of pins and needles (paraesthesia) Poor memory Impaired cognitive performance Depression Weakness Impaired digestion Inflammation Gastrointestinal lesions Neurological damage Since B12 is primarily found in animal products, any change in one’s diet that leads to a decrease in the consumption of such products — such as a vegan , vegetarian, or low-fat diet — can increase the chance of a person developing a B12 deficiency

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It is a marketing term borrowed from the skincare space, where it refers to the way skin looks rather than to a specific clinical measurement