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Uncontrolled hyperglycemia with persistent ROS generation leads to apoptosis of several types of cells, including epithelial cells of the proximal tubule, damaging the nuclear DNA and mitochondria's genetic material that promotes loss of kidney function
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found that pretreatment of HER2-amplified breast cancer line BT474 parental cells with the GPX4 inhibitor RSL3 reduces the amount of persister cells that remain after subsequent treatment with the HER2 inhibitor lapatinib, suggesting that GPX4-sensitive cells pre-exist [40]
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