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N.EzeriņaD.et al (2021)

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Although it is still not clear whether ROS can directly oxidize MAPK, numerous studies have shown that protein phosphatases including protein tyrosine phosphatases (PTPs) such as PTP1B, serine/threonine phosphatases such as protein phosphatase 2A (PP2A), and some dual specific MAPK phosphatases (DS-MKPs) such as MKP-1 and MKP-3 can be inactivated by ROS through oxidation of critical cysteine residues in their active sites, associated with a sustained activation of MAPK [203–213]