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Keywords: vitamin B12, neurological diagnosis, diagnosis, treatment concept, homocysteine Vitamin B 12 deficiency is more widespread in the population than has been assumed so far (1, 2)

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In a recent phase II study [127], tivantinib showed promising results in patients with advanced HCC and Child–Pugh class A cirrhosis, improving mPFS (2.7 months vs 1.4 months, P = 0.03) compared with placebo in a subset of patients with high MET expression (MET-high)