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However, because regulation of EPO expression is highly sensitive to hypoxia compared with other HIF targets, such as VEGF , 68 , 139 HIF-PHIs may achieve desirable proerythropoietic effects at doses that do not elicit a broader spectrum of HIF responses in CKD patients, including stimulation of VEGF-dependent pathways
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Likely, this might also be the supportive part to the general interaction
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