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By synthesizing this 16-amino-acid fragment and substituting a tyrosine for the native phenylalanine at position 176, the team created AOD-9604, a peptide that could stimulate fat breakdown without the metabolic complications of full-length growth hormone
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It was previously approved by the FDA for diagnostic evaluation and treatment of pediatric GH deficiency and is now widely used off-label in research and clinical settings to address adult-onset GH insufficiency and age-related hormonal decline
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