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4.3 Future directions Next-generation approaches, focusing on the tissue-restricted or cell-targeted delivery of checkpoint modulators, are being developed to tackle the above issues
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Recent hypotheses suggest that GIP induces appetite suppression through independent receptors in the brain, mitigates gastrointestinal side effects of GLP-1 action, and prevents desensitization of GLP-1 receptors, thereby acting as a biased GLP-1RA [87]
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