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Proposed explanations include local tissue activity and downstream signaling cascades outlasting the peptide itself
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In silico Analysis Pathogenicity of the identified variant was evaluated with different online mutation prediction tools such as MutationTaster (mutationtaster.org), DNN ( FATHMM (fathmm.biocompute.org.uk), LRT (genetics.wustl.edu/jflab/lrt_query.html), VarSome ( CADD—Combined Annotation Dependent Depletion ( and MutationAssessor (mutationassessor.org)
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