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In the absence of disease, the vasculature remains the tissue with the greatest senescent cell burden in old mice and in models of premature aging in mice [12] , suggesting that the vasculature is particularly vulnerable to cellular senescence
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proposed that the “PFC-Hip-Amy” circuit exhibits different activity patterns during various sleep states such as wakefulness (W), Non-Rapid Eye Movement (NREM), and Rapid Eye Movement (REM) sleep
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