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Key points Mechanisms by which microbes might cause rheumatoid arthritis (RA) or spondyloarthritis (SpA) include molecular mimicry, microbial translocation, dysregulation of mucosal immunity, production of immunomodulatory metabolites and immune cell trafficking
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This is consistent with prior preclinical literature demonstrating RV to have analgesic properties as a cyclooxygenase inhibitor (COX I & COX II) 69
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