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We explored herein the promising results of the therapeutic use of exogenous melatonin combined with exosomes derived from several tissues (e.g., mesenchymal stem cells), and in many pathological conditions such as ischemia-reperfusion injury, obesity, hepatocellular carcinoma, oral squamous cell carcinoma, chronic kidney disease, ischemic brain syndrome, neurodegenerative diseases like Alzheimer’s disease, acute inflammatory colitis, diabetes-related wound healing, vascular calcification, ageing, and also in embryonic development

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This treatment caused a significant decrease in the levels of inflammatory and oxidative colonic markers: MPO activity, COX2, signal transducer and activator of transcription 3 (STAT3) and NF-kB colonic expression, TBARS colonic levels and DNA damage [104]