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Moreover, when IGF-1R was combined with an anti-PD-1 antibody, the growth of experimental pancreatic ductal adenocarcinoma liver metastases was inhibited and the response of T cell was further enhanced

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For site M ·Γ / 2 i , we define as the site-wise entropy of the amino acid distribution of the ancestral set 𝒮 anc , taking the single-point frequencies f of the amino acids as a probability distribution per site