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Animal models that lack genes responsible for protecting the gut’s epithelium, such as Mdr1a−/−, Irgm1−/−, and Sod2−/− transgenic mice, exhibit an increased presence of impaired mitochondria in intestinal cells and are more susceptible to experimentally induced colitis (56)
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[DOI: 10.1371/journal.pmed.1000100] [DOI] [PMC free article] [PubMed] [Google Scholar] Lindenbaum 1994 Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH
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