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At this low price, the Sinaloa and Jalisco Cartels in Mexico, which are responsible for producing the majority of illicit fentanyl being trafficked in the United States, have been using xylazine as an adulterant to increase their profit, since its psychoactive effects reduce the amount of fentanyl or heroin needed to be included in a psychoactive powder mixture

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In doing so, we allow the clinician to extrapolate the potential impact that an inducer/inhibitor may have on these drug concentrations