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Among cardiologists, endocrinologists and internists surveyed, nearly one quarter report that patients are already asking about triple-agonist therapies (informally known as “GLP-3s”) like retatrutide, a compound still in Phase III trials

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These data suggest that the synergy between GHSR1a and D1R is due to GHSR1a switching from Gα q/11 coupling to Gα i/o coupling, a G-protein that is not associated with D1R or GHSR1a when expressed alone