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Because TIGIT is very frequently co-expressed with PD-1 on T cells in tumor tissues (most TIGIT+ cells are also PD-1+, and most PD-1+ cells co-express TIGIT) and PD-1 blockade has been shown to compensatorily increase TIGIT expression on the surface of cytotoxic T lymphocytes, concomitant blockade of both receptors may more effectively relieve suppression of the antitumor response than targeting either pathway alone [451,458]

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