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Opioids are metabolized mainly in the liver through two major enzyme systems, cytochromes P450 (CYP450) (particularly CYP3A2, CPY3A4 and CYP2C8) and UDP-glucuronosyltransferases, to produce morphine 3-glucuronide and to a lesser extent, morphine 6-glucuronide, morphine 3-sulfate and normorphine [20,21]