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Collectively, these studies delineate a complex and multifaceted relationship between TG levels and depression: elevated TG levels not only precede the onset of depression but also correlate with its symptomatic severity and underlying pathophysiological mechanisms
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The intrinsic apoptosis pathway is controlled mainly by mitochondrial outer membrane permeabilization, BCL-2 family proteins, cytochrome c release, apoptosome formation, caspase-9 activation, and downstream executioner caspase-3/7 activation
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