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We developed a novel, discovery-based immunopeptidomics approach in which HLA-DR–presented peptides are identified directly from patients’ synovial tissue by nanoscale liquid chromatography–tandem mass spectrometry (nano-LC-MS/MS), followed by determination of the antigenicity of the phenotype-specific peptides and their proteins of origin using patient samples (13, 14)
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Size:22 lb / 10 kg
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