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However, the C max of free resveratrol is typically extremely low: 50 μ M ) than those observed in plasma after ingestion of a cup of coffee (436), these results do indicate that dihydrocaffeic acid may function as an intracellular antioxidant

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Another study demonstrated that lactate induces lactylation of HMGB1 in RAW 264.7 cells, which can be antagonized by c646, an inhibitor of p300/CBP