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elucidated the interplay between CD44v9-containing isoforms and cystine-glutamate transporter xCT, a key player in glutathione (GSH) synthesis, reactive oxygen species (ROS) inactivation and ferroptosis regulation (Figure 8

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Therefore, predicting the appropriate dose and route of administration to enhance desired effects and minimize adverse consequences becomes challenging in the absence of enough clinical data supporting the safety and efficacy of these compounds