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Circulating bile acid metabolites have been shown to be lower in PwMS compared to healthy controls and this alteration in bile acid metabolism may relate to alterations in the gut microbiome 233,234
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Methods: C57BL/6 mice were treated with CCl 4 for 16 wks to induce Type C HE and received a senolytic cocktail of dasatinib and qercertin (D/Q via oral gavage) starting after 8 wks of CCl 4 injections
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