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The absence of human trials is a significant limitation

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demonstrated that GHRP-2 combined with GHRH produces synergistic GH release approximately 2-3 times greater than either peptide alone, establishing the scientific basis for combination protocols Aging research : Clinical studies in elderly subjects showed that GHRP-2 restored GH pulse amplitude toward youthful levels, suggesting utility in age-related GH decline The breadth of clinical data, combined with regulatory approval, provides GHRP-2 with a stronger translational evidence base than most other GHRPs