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However, MOMP is regulated by the protein Bcl-2, which is an important factor influencing the release of apoptotic factors like cytochrome c, which activates caspases and initiates cell death 90

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(2) In NK cells, upregulation of inhibitory receptors NKG2A, TIM-3, Toll-like receptor 2 (TLR2), CD94, and PD-1, as well as decreased secretion of tumor necrosis factor-α (TNF-α) and interferon-gamma (IFN-γ), are all factors promoting the occurrence and development of HCC