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X 21 is independently selected from halo, C 1 -C 4 alkyl, hydroxyl, C 1 -C 4 alkoxy, halo- substituted C 1 -C 4 alkyl, hydroxyl-substituted C 1 -C 4 alkyl, (C 1 -C 4 alkoxy)C 1 -C 4 alkyl, halo- substituted C 1 -C 4 alkoxy, amino, N-(C 1 -C 4 alkyl)amino, N,N-di(C 1 -C 4 alkyl)amino, [N-(Ci- C 4 alkyl)amino]C 1 -C 4 alkyl, [N,N-di(C 1 -C 4 alkyl)amino]C 1 -C 4 alkyl, N-(Ci- C4 alkanoyl)amino, N-(C 1 -C 4 alkyl)-N-(C 1 -C 4 alkanoyl)amino, N-[(Ci- C4 alkyl)sulfonyl]amino, N-[(halo-substituted C 1 -C 4 alkyl)sulfonyl]amino, C 1 -C 4 alkanoyl, carboxy, (C 1 -C 4 alkoxy)hydroxyl, cabamoyl, [N-(C 1 -C 4 alkyl) amino]carbonyl, [N,N-di(Ci- C4alkyl)amino]carbonyl, N-carbomoylamino, cyano, nitro, mercapto, (C 1 -C 4 alkyl)thio, (C 1 -C 4 alkyl)sulfinyl, (C 1 -C 4 alkyl)sulfonyl, aminosulfonyl, [N-(C 1 -C 4 alkyl)amino]sulfonyl and [N,N-di(C 1 -C 4 alkyl)amino]sulfonyl
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In addition to explicit metabolite concentrations, the present study also involved metabolic ratios to gain further insights into disease pathophysiology and pathway dynamics based on statistical correlation analysis
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