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Metabolism of dopamine has been suggested to be a prominent producer of reactive oxygen species in the brain ( 2 O 2 which when in the presence of iron or oxygen can form the more active hydroxyl radical (
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These PA support parasite replication and persistence and are essential for trypanothione sysnthesis, a thiol-based antioxidant that protects Leishmania from peroxynitrite-mediated cytotoxicity (29)
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