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Mechanism of glutathione peroxidase (GPx) redox pathway. Selenol (-SeH)... | Download Scientific Diagram

It is worth noting that the “direction” of this selective effect—that is, whether a specific mtDNA mutation is harmful, neutral, or beneficial—depends entirely on the microenvironment in which the cell is located

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In several disease models, enhancing MnSOD levels or function, whether through genetic means, transcriptional activation, or targeted post-translational modulation, confers protective effects, while its deficiency exacerbates oxidative damage and dysfunction