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In addition, AgRP co-localizes with AR in the hypothalamus, androgens regulate metabolic homeostasis by affecting these neurons, and prenatal testosterone or DHT exposure decreases the co-localization of AgRP and insulin receptors, which subsequently affects hepatic insulin sensitivity (42–44)

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Homozygous jvs/jvs mice develop severe fatty liver and die at a young age because the lack of carnitine prevents the transport of long-chain fatty acids and accumulation of fat in various cells 11