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Thus, BPC 157, along with Nab2 , could serve as a controlling feedback mechanism and guarantee transient and controlled Egr1 activity (Tkalcevic et al., 2007) (consequently, Egr1 decreases later in the 24 hr period in the inferior caval vein while remaining increased in ovarian veins (Vukojevic et al., 2018), similar to its presentation in the hippocampus of ischemia/reperfusion rats)

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Of note, unlike carbonyl scavengers that target only a single line of defense, NRF2 regulates genes across all three defense lines, including those encoding antioxidant enzymes, RLA-detoxifying enzymes, and components of the 20S proteasome and lysosome, such as Proteasome Subunit β-Type 5 (PSMB5), PA28αβ, and Sequestosome-1 (p62) (36, 216–223)

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