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In the early stages of Alzheimer’s disease (AD), ACOX1 and its transcriptional regulators PPARα and peroxisome proliferator-activated receptor gamma coactivator 1 α (PGC-1α) are induced to be highly expressed due to damaged mitochondria and increased oxidative stress but are significantly reduced in late stages (56)
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Hjort Telhede E, Arvidsson S, Karlsson S, Ivarsson A
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